Management of Hepatic Encephalopathy
نویسندگان
چکیده
Hepatic encephalopathy (HE), the neuropsychiatric presentation of liver disease, is associated with high morbidity and mortality. Reduction of plasma ammonia remains the central therapeutic strategy, but there is a need for newer novel therapies. We discuss current evidence supporting the use of interventions for both the general management of chronic HE and that necessary for more acute and advanced disease.
منابع مشابه
Evaluation of the role of TLR4 in endotoxin-induced hepatic encephalopathy in rats with biliary cirrhosis
Background: Hepatic encephalopathy is defined as a neuropsychiatric brain dysfunction in acute or chronic liver failure. Infection and inflammation have crucial role in its pathophysiology. The purpose of our study was to demonstrate the relationship between toll-like receptor 4 (TLR4) expression and the encephalopathy induced with endotoxin in biliary cirrhotic rats. Methods: The present stud...
متن کاملHow to diagnose and manage hepatic encephalopathy: a consensus statement on roles and responsibilities beyond the liver specialist
INTRODUCTION Hepatic encephalopathy is defined as brain dysfunction caused by liver insufficiency and/or portosystemic shunting. Symptoms include nonspecific cognitive impairment, personality changes and changes in consciousness. Overt (symptomatic) hepatic encephalopathy is a common complication of cirrhosis that is associated with a poor prognosis. Patients with hepatic encephalopathy may pre...
متن کاملEvaluation and Management of Hepatic Encephalopathy: Current Status and Future Directions
Hepatic encephalopathy is a spectrum of neurocognitive manifestations often seen in patients with liver injury or rarely in patients with portosystemic shunting without liver injury. It can be divided into minimal (covert) hepatic encephalopathy and overt hepatic encephalopathy, depending on the severity. Patients with hepatic encephalopathy have compromised clinical outcomes, decreased quality...
متن کاملRifaximin in the treatment of hepatic encephalopathy
Hepatic encephalopathy is a challenging complication in patients with advanced liver disease. It can be defined as a neuropsychiatric syndrome caused by portosystemic venous shunting, ranging from minimal to overt hepatic encephalopathy or coma. Its pathophysiology is still unclear, although increased levels of ammonia play a key role. Diagnosis of hepatic encephalopathy is currently based on s...
متن کاملA Rational Approach to Understand and Manage Hepatic Encephalopathy (HE/PSE) in Chronic End-Stage Liver Disease (Cirrhosis)
64 Hepatic encephalopathy (HE) or Portosystemic encephalopathy (PSE) in end-stage liver disease (ESLD) such as cirrhosis of the liver is a reversible and recurrent disorder of neurological function caused by liver disease or portosystemic shunting of blood or both. In this article only hepatic encephalopathy (HE) in chronic end-stage liver disease (ESLD) will be discussed. Hepatic encephalopath...
متن کاملL-Ornithine-l-aspartate in the management of hepatic encephalopathy: a meta-analysis.
BACKGROUND AND AIM Hepatic encephalopathy continues to be a major clinical problem and the current decade has not witnessed major therapeutic breakthroughs in this area. L-ornithine-l-aspartate (LOLA) is not frequently used as there are still some reservations about its benefits. The present study aimed to assess the effectiveness and safety of LOLA in the management of hepatic encephalopathy. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2011 شماره
صفحات -
تاریخ انتشار 2011